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The dose-response relationship is entirely different from semaglutide, where dosing follows a fixed titration schedule
Nuclear receptor agonists, particularly FXR modulators, have demonstrated efficacy in attenuating bile acid cytotoxicity, enhancing hepatobiliary excretion, and mitigating bilirubin accumulation [54]
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Several technical reasons may explain our distinctive findings, including differences in the microbiome sampling site, the limited n per group, singly housing mice, or the use of highly similar lean, Western, and high-fat diets which systematically exchanged fat content with carbohydrate content
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