does semaglutide cause low iron Nutritional Deficiencies with weekly GLP-1 Receptor Agonists (Ozempic & Mounjaro): What patients Need to The effect of semaglutide on

10.1523/JNEUROSCI.1365-09.2009 Summary Keywords NMDA receptors, GluN2B, GSH metabolism, gamma-Glu-Glu, partial effect Citation Sebih F, Mokrane N, Fontanel P, Kayatekin M, Kaabeche M, Guiramand J, Cohen-Solal C, Cens T, Rousset M, Charnet P, De Jsus Ferreira M-C, Thibaud J-B, Mnard C, Cantel S, Rolland V, Vignes M and Roussel J (2022) The Glutathione Metabolite -Glutamyl-Glutamate Partially Activates Glutamate NMDA Receptors in Central Neurons With Higher Efficacy for GluN2B-Containing Receptors

Regarding safety, the GLP-1 receptor agonists group reported a higher frequency of all adverse events, significantly in dyspepsia, vomiting, and constipation, with non-significant differences in diarrhea, headache, and fatigue

For others, side effects may be minimal or none and weight loss slow down after an initial large loss

One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition