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The mechanisms by which TMAO raises CV risk and accelerates atherosclerosis are not well understood, but studies have shown that TMAO arising from both choline and L-carnitine supplementation in mice may inhibit reverse cholesterol transport 35 and enhance foam cell formation in both arterial and peritoneal cavity 47
Unlike deficiency states, which produce well-characterised neurological and haematological symptoms, there is no clearly defined clinical syndrome associated with B12 excess from supplementation alone
Kennedy DO, Veasey R, Watson A, Dodd F, Jones E, Maggini S, Haskell CF
Cells, 9 (9), 1970
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