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In addition to the lowering effect of APAP on GSH in the liver, where detoxification occurs, APAP treatment decreases liver Cys concentration, plasma free cyst(e)ine (i.e
DLD ) (5, 53, 54)
PEA is an endogenously produced lipid mediator that helps maintain neuroimmune balance and inflammatory tone
Genetic polymorphisms are heritable changes in DNA sequences as consequence of single-nucleotide polymorphisms or stable point mutations that may partially alter enzyme activity, or large deletions in coding sequences resulting in a null phenotype 24,34
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