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Reviewed February 2026
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Stopping GLP-1 Prior to Surgery: UK Perioperative Guidance Glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide, dulaglutide, and liraglutide are increasingly prescribed for type 2 diabetes and weight management across the UK
It is widely known that mitochondrial dysfunction (high ROS production, apoptotic cells, decreased m, and low cellular ATP levels) boosts the pathogenesis of KOA because it involves lipid homeostasis and cytokine release and promotes cell apoptosis [14, 15]
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