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Patients have said they experienced these side effects after starting GLP-1 drugs: Irritation around the spot you inject the drugs, including itch, rash, and swelling Excessive sweating Dry skin caused by hormone changes and eating and drinking water less often Slower nail growth and brittle nails from significant weight loss Loose skin that folds on itself, causing rashes where skin touches skin Acne breakouts due to hormone changes Do GLP-1 drugs cause hair loss