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3f), whereas mechanical allodynia was dose-dependently alleviated in the groups treated with exendin 939 (5 or 10 g) or BCTC (0.5 g), a widely used TRPV1 inhibitor 40

Standard FDA-approved dosing escalation The FDA-approved tirzepatide dosing schedule, used in the SURMOUNT and SURPASS clinical trials, follows this pattern: Weeks 1 to 4: 2.5 mg once weekly (starting dose) Weeks 5 to 8: 5 mg once weekly Weeks 9 to 12: 7.5 mg once weekly (optional increase) Weeks 13 to 16: 10 mg once weekly (optional increase) Weeks 17 to 20: 12.5 mg once weekly (optional increase) Week 21 and beyond: 15 mg once weekly (maximum dose) Each dose increase happens after a minimum of four weeks at the current dose

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R.SharpeA.McGregorL.BekkaouiD.et al