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According to the results, the elimination half-life (t 1/2 ) of the prototype BPC157 was less than 30 min, and BPC157 showed linear pharmacokinetic characteristics in rats and beagles at all experimental doses
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On the other hand, macrophages respond to various stimuli in the microenvironment and are reprogrammable into different functional subtypes after activation, usually converting in two directions: pro-inflammatory and anti-inflammatory subtypes, which are not fixed states but are mutually convertible for suitability to the changing needs and environments (59)
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