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Theres no consistency
Feeling cold is not listed as an official adverse effect in the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), though some patients report increased cold sensitivity during treatment
Phase 1 GLP-1 and GLP-1/GIP receptor agonists should be used as an adjunct to a reduced-calorie diet and increased physical activity for weight management, including weight maintenance, in: BMI 38 kg/m 2 (or 35 kg/m 2 in ethnic groups known to be at equivalent risk of obesity consequences at lower BMI than White ethnicity), and one or more obesity-related clinical condition, or Edmonton Obesity Staging System stage 3 or 4 (see Box 1
These studies consistently demonstrate measurable reductions in fine wrinkles, improvement in mottled hyperpigmentation, increased dermal collagen (confirmed on biopsy), and smoother skin texture over 24 to 48 weeks of use
