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Real-world persistence is low: about half discontinue within a year and roughly three-quarters within two years , often due to cost or side effectsraising the risk of rebound weight and lost health gains (Scientific American on discontinuation rates)
Many patients assume they are the same thing, but while GLP-1 medications are technically peptides, not all peptide therapies are designed for weight loss
Phase 3 trials recruit differently, run differently, and aren't directly comparable
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