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First, individual patient data (IPD) were not available, which restricted our ability to perform subgroup analyses based on detailed patient-level variables such as ethnicity, cancer stage, or medication adherence

By improving HRV, L-carnitine helps shift the autonomic nervous system out of chronic sympathetic overdrive (the "fight or flight" state) and enhances parasympathetic vagal tone (the "rest and digest" state), promoting a calmer, more regulated nervous system response to physical stressors

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The mice were housed at a constant temperature and humidity under a 12-h/12-h lightdark cycle with free access to standard food and water for at least 1 week prior to the beginning of the experimental procedures