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These examples use the PT-141 10 mg / 3.0 mL reconstitution concentration for illustrative math only
Weight loss was initially observed as a side effect of GLP-1 medications in clinical trials testing the drugs for type 2 diabetes
The increased pK a appears dependent on the ionized thiolate, since S-methylglutathione is without effect on the ionization of Tyr9
Systematic comparative data is limited, but the hypothesis is supported by general peptide chemistry principles around salt form and stability
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