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Methods All mouse experiments were approved by the Animal Ethical and Welfare Committee of the Sixth Affiliated Hospital of Sun Yat-sen University carried out following their legal requirements
Additional analyses have shown consistent results across most outcomes examined, which included a variety of cardiovascular diseases, such as incidence of atrial fibrillation, 239 coronary heart disease, incidence of hypertension, 216 and incidence of stroke, 71 diabetes, 240 chronic kidney disease, 222 mild cognitive impairment, Parkinsons disease, 241 and multiple sclerosis
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