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Others (e.g., Ozempic, Mounjaro, Trulicity, Victoza, and Rybelsus) are diabetes drugs and would be prescribed off-label for weight management

Adjusting tirzepatide titration schedules can reduce side effects without compromising long-term efficacy

382,383 An in-depth understanding of the underlying mechanisms of cellular pyroptosis is essential to determine its role in the pathogenesis of DPN and develop effective therapeutic agents targeting the pyroptosis signaling pathway to alleviate neuropathic symptoms

To address this, researchers are exploring alternative routes of administration , including oral, transdermal, and inhalable formulations