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Two metabolites, allopregnanolone and pregnanolone, positively modulate that receptor while two other metabolites, isoallopregnanolone and epipregnanolone, have the opposite effect
Six weeks of GLP-1 infusion resulted in significant improvements in fasting (decrease of 4.3 mM glucose) and 8 h mean glucose (decrease of 5.5 mM), fasting and mean 8h free fatty acids, a reduction in HbA1c from 9.2% to 7.9%, a decrease in fructosamine from 349 uM to 282 uM, and a reduction in gastric emptying 3,4
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