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The correct interpretation of any result depends on the biological model, assay sensitivity, positive and negative controls, exposure period, analytical method, and the reproducibility of the dataset
And the one patient that I had that it didnt work on, he had confirmed osteoarthritis in his neck
Studies were included regardless of publication status or language, but we excluded any preclinical studies (animal or in vitro), case reports or small case series (sample size 90% in most cohorts) and obese (mean BMI ~ 3542 kg.m 2 )
The results were provocative, weight loss with participants losing up to 28.7% of their total body weight over 68 weeks [33]
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