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et al., Biomedicines, 2022

PubMed catalogs the TB-500 and thymosin beta-4 tendon research base

Andreassen and colleagues (J Med Chem, 2021) reported a design campaign that combined sequence substitutions to suppress fibrillation with a fatty-acid acylation that promotes albumin binding, yielding a molecule with a much longer reported plasma half-life in their preclinical models