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Treatments administered to primary AML cells included oridonin, orid-liposome, orid-liposome-MAL, and TLR2 pep-orid-liposome, each at a concentration of 4 M
Pharmacovigilance refinement using MedDRA + Re-run disproportionality analyses with (a) Standardised MedDRA Queries where applicable, (b) stratification by reporter type (healthcare professional vs consumer), co-medication filters (exclude SGLT2), and time-to-onset modelling to separate early dehydration-linked symptoms from later endocrine/tissue changes
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Further studies indicated that pyridoxine treatment of astrocytes resulted in PKM2 dimerization (Fig
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