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5 Conclusions Summarizing the above results, we speculate that glutathione can protect the liver of bullfrogs by repairing liver tissues, enhancing the antioxidant ability of bullfrogs, affecting the related metabolism of the body, repairing liver damage, up-regulating Autophagy - other, Necroptosis and ErbB signaling pathway, and It also up-regulated Autophagy - other, Necroptosis and ErbB signaling pathway, and down-regulated Sphingolipid metabolism and D-Amino acid metabolism pathway, and regulating the disorder of liver lipid metabolism