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Both are given as a subcutaneous injection once per week
Research on lyophilized peptide integrity has demonstrated that the freeze-dried form maintains stability for 1224 months at -20C, but exposure to room temperature accelerates degradation kinetics
Mild nausea may occur but usually passes quickly
The @NEJM just reported impressive weight loss with Orforglipron, the first oral small-molecule GLP-1 receptor agonist
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