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"Physicians should be concerned about the increased risk of gallbladder or biliary disease associated with GLP-1 RA use, especially at the higher doses recommended for weight loss," the authors write

The resulting BBB-on-chips are anatomically similar to brain capillaries since endothelial cells self-assemble into a vascular network with pericytes and astrocytes at their surface (Campisi et al., This generation of BBB models has exploited 3D printing and bioprinting (Ho et al., 2015), reducing the time and technical expertise needed to reproduce complex model architectures