sglt2 and glp 1 combination Effect of treatment with glucagon-like peptide-1 receptor agonists sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study SGLT2 Inhibitors vs. GLP-1 Agonists

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GLP-1 receptors are expressed primarily in pancreatic islets, the gastrointestinal tract, kidney, heart, and certain brain regions, with limited expression in skeletal muscle tissue

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Secondly, they often contain stimulant ingredients that can cause psychiatric side effects like heart palpitations and anxiety