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These conditions typically present with symmetrical muscle pain, morning stiffness lasting more than 30 minutes, and elevated inflammatory markers like C-reactive protein or erythrocyte sedimentation rate
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The Gs heterotrimer engages with the receptor through the same interface observed in peptide-agonist structures, with the alpha-5 helix of Gs-alpha inserting into the intracellular cavity and making contacts with TM3, TM5, TM6, and intracellular loop 2 (ICL2)
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