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This epigenetic alteration results in cancer progression, drug resistance [34], metastasis and stemness induction [35, 36], metabolic alterations by affecting enzymes involved in the tricarboxylic acid cycle (TCA), and carbohydrate, amino acid, fatty acid, and nucleotide metabolism [35], hence opening the way to the generation of novel therapeutic strategies against lysine lactylation, not only regarding histones (Fig

The key results are outlined in Figure 10 and described below

in vivo The plasma half-life is 46.1 h in mini-pigs following i.v

Sharp, localized chest-wall pain linked to nausea or vomiting typically improves with hydration and anti-nausea strategies