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Time in range improved from 69.4% to 74.2%, daily insulin use fell by 11.3 units, and participants reduced carbohydrate intake and body weight with no increase in hypoglycemia
Starting at the lowest effective dose also minimizes early symptoms
To assess changes over time in side effects as rated by the UKU scale, difference scores for side effects were calculated by subtracting the baseline score on the items of the UKU side effects rating scale from the actual scores over time
GSH is also a co-substrate used by GPX to reduce ROS 51
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