However, very high doses unlikely providing proportionally greater benefits due to receptor saturation
This copper-binding tripeptide activates TGF-beta/SMAD pathway signaling, stimulates collagen I and III synthesis, upregulates TIMP-1 and TIMP-2 to protect collagen from degradation, and modulates gene expression across approximately 4,000 human genes
Annu Rev Immunol
Thank you Chu Hoon Ding Connor, I am excited to learn more, I am a new collagen peptide supplement user, and already feel less aches Im in heaven, this article I saved to my phone, I grew up with bone broths, and Im trying to learn as much as I can now on the health side of this adventure,, my grandparents had no concern about temperature except the hotter the better haha and no use for vinegars in the broth my mom was the same, thank you for posting this, bone broths r going to become a routine now hugs from ohio Tammy Null Hi Louzana, I would definitely stop taking collagen (like you have done) in your case
