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This protective effect could be attributed to weight loss, better blood sugar control, or even direct effects on heart function
10.1097/JCP.0b013e31829a83f5 65
Upon activation, the tyrosine kinase activity of the IGF-IR entails sequential phosphorylation events at residues Y1135, Y1131, and Y1136, which produce conformational changes in the subunits to create docking sites for downstream signaling molecules and their phosphorylation (14)
www.nejm.org/doi/full/10.1056/NEJMoa2032183.
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