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Some practitioners advocate weight-based dosing (e.g., 2.5-5 g/kg daily), while others use fixed doses (250-500 g daily) regardless of body size

*Correspondence: Bassem Sadek, [email protected] This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

However, it has been recently described that mTORC2 also possesses tyrosine phosphorylation capacity [118], and that it phosphorylates tyrosines on IRS and tyrosine kinases in both receptors, IGF-1 and IR, thus reinstituting the signal of the activated receptors [118]

It also plays a crucial role in the functioning of the nervous system, as it is needed to produce the protective covering of nerves known as myelin