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To a large extent, these changes are also characteristic of metabolic syndrome, which affects approximately 25% of the worlds adult population and is associated with insulin resistance, hypertension, dyslipidemia and obesity, factors that increasingly lead to cognitive impairment and brain atrophy

Saunders says they should never be prescribed in the absence of a comprehensive evaluation, lifestyle management, and tons of ongoing education and support. Patients in the SURMOUNT-OSA clinical trial received regular lifestyle counseling sessions focused on maintaining healthy nutrition while following a 500 calorie per day deficit and at least 150 minutes of physical activity per week

UK EMC, 2024