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Tirzepatide and semaglutide, in rare cases, may cause serious side effects, which include: Pancreatitis (inflammation of the pancreas) Vision problems Kidney problems, including kidney failure Gallbladder problems Pulmonary aspiration during sedation or procedures (tell your healthcare provider you use tirzepatide or semaglutide if you are planning any medical procedures) Before using tirzepatide or semaglutide, tell your healthcare provider about all of your medical conditions, medical history, and family history