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Phentermine (Adipex-P): What It Is: Sympathomimetic amine (stimulant) Appetite suppressant Oldest weight loss medication still available Effectiveness: Average Weight Loss: 5-7% of body weight Short-term use only (FDA-approved for 12 weeks) Weight often regained after stopping Mechanism: Stimulates norepinephrine release Decreases appetite Increases energy expenditure Side Effects: Increased heart rate and blood pressure Insomnia Nervousness, anxiety Dry mouth Constipation Potential for dependence Major Limitations: Controlled substance (Schedule IV) FDA-approved for short-term only (12 weeks) Not a long-term solution Cardiovascular concerns Risk of abuse Cost: Generic: $20-$50/month Usually not covered by insurance Who Should Consider: Need short-term appetite suppression Kickstart weight loss before switching to long-term option Cant afford other medications No cardiovascular disease or substance abuse Most experts dont recommend phentermine due to short-term limitation and rebound weight gain

You might start with liraglutide but find the daily injections inconvenient, or you may find that your weight loss has plateaued

Fu L, et al