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The physicochemical stability of BPC-157 across various biological environments may contribute to its apparent safety profile, as the peptide appears to be well-tolerated when administered via different routes including oral, subcutaneous, and intramuscular administration

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Bulk RNA sequencing revealed that gene expression changes were most pronounced in the MBH, where RAMP1/3 KO mice treated with sCT showed extensive differential expression of over 1,700 genes, while WT mice exhibited comparatively minor transcriptional shifts