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Studies suggest that tirzepatide can lead to greater weight loss than Ozempic , with some patients losing more than 20% of their body weight

For this reason, the upper arm is most practical when someone else administers the injection for you, or when you are using a pre-filled pen device that simplifies the process

That loss, coupled with low vitamin D levels, may increase the risk for osteoporosis in these individuals, Ortiz-Pujols said

It adds that pregnancy, breastfeeding, and severe renal or hepatic impairment require specialist assessment, and that oral mucosal irritation is possible, so pre-existing oral conditions warrant provider evaluation