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Chow ES, Long DM, Giebultowicz JM
In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]
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The authors never discussed the possibility that PGN complexed with the added proteins to effectively reduce the active concentration of the PGN, or the fact that PGN and CGN are two different molecules, by molecular weight and physiochemical properties, and that those properties could have played a role in the differences observed
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