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That signal comes from two sources: adequate protein (covered in my protein calculator for GLP-1 users and How Much Protein Per Day For Women) and mechanical loading through resistance training

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PCO 2 , 19.9 mmHg

In simple obesity (body mass index = 30.034.9 kg/m2), the annual probability of attaining normal weight was 1 in 210 for men and 1 in 124 for women , increasing to 1 in 1290 for men and 1 in 677 for women with morbid obesity (body mass index = 40.044.9 kg/m2)