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Safety considerations and managing sensitive eye area Periorbital skin sensitivity creates unique safety considerations beyond general peptide safety profiles due to extreme thinness increasing absorption and irritation potential, proximity to eyes creating contamination risk, and higher reactivity to active ingredients compared to other facial areas

the DOX + Metformin group received metformin (300 mg/kg/day, p.o.) (Ma et al., 2018) for 21 days in addition to DOX as above

Instead of targeting only one pathway, it influences several biological processes that together create stronger, thicker, and healthier hair

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