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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

Even if few studies have been reported of transplantation after ex-vivo drugs administration, targeting the biological pathway associated to kidney failure (i.e

Wang, G., et al., N-acetylcysteine in Cardiac Surgery: Do the Benefits Outweigh the Risks

Its the - sodium form - cousin of the famous NMF , hyaluronic acid (HA)