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The last factor is particularly relevant in treatments that depend on the antioxidant/ pro-oxidant property of vitamin C, because it can be readily manipulated and controlled in vivo to achieve desired effects [34]

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Accumulated ROS under pathological conditions-such as inflammation, ischemia, or denervation-activate upstream kinases (ASK1, MKK3/6, MKK4/7), leading to p38 and JNK phosphorylation

In this regard, antioxidant effects characterized by decreased MDA and increased TAS or GSH have been widely reported for natural secondary metabolites in gastric injury settings (Gao et al