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Baseline liver enzyme assessment is reasonable for patients with: Pre-existing liver disease or elevated baseline transaminases Metabolic syndrome or clinical features suggesting MASLD Concurrent use of other potentially hepatotoxic medications Obesity (BMI 30 kg/m) with additional metabolic risk factors History of excessive alcohol consumption For patients with abnormal baseline liver enzymes, periodic monitoring every 3-6 months during the first year of therapy allows clinicians to assess treatment response and detect any unexpected changes
doi: 10.1038/s42255-024-00985-1 2
Rather than trying to deliver tirzepatide orally, they developed an entirely different molecule
Laboratory monitoring Your provider should order baseline labs before starting the combination and repeat them at 4-8 week intervals
