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AMPK activation promotes fat oxidation and glucose uptake, supporting the metabolic claims
2026;15(1):e70001
However, the observational nature of this study underscores the need for further trials to validate these findings, explore long-term outcomes, and assess tirzepatides efficacy across diverse HFpEF populations
Tirzepatide, the active ingredient in Mounjaro and Zepbound, is a 39-amino acid dual agonist targeting both GLP-1 and GIP receptors, also incorporating a fatty acid modification for half-life extension, and is the most commercially significant synthetic peptide ever produced at scale
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