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Epithelial restitution and barrier integrity changes would be expected to manifest as improvements in intestinal permeability assays and endoscopic healing scores, such as Simple Endoscopic Score for Crohns Disease [SES-CD] or Mayo Endoscopic Score ( Animal models have mapped specific target cell types to downstream restitution programs
Imagine a scenario where a comprehensive treatment plan involves neurological evaluation, psychological support, nutritional guidance, and, where appropriate, metabolic modulation
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