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Antithrombotic properties Recent investigations show that ESC and esculin pentasulfate (EPS), a heavily sulfated esculetin derivative, significantly reduced thrombus weight and length, prolonged APTT, PT, and TT, and confirmed strong systemic anticoagulant activity in rat venous thrombosis models induced by inferior vena cava ligation

By leveraging the olfactory epithelium and its associated neural pathways, this method capitalizes on the large surface area, efficient blood flow, and neural connections of the nasal mucosa to provide a relatively non-invasive approach towards efficient peptide delivery into the brain [41-46]

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IDF diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021