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The cardiovascular outcomes trials that enrolled tens of thousands of patients with type 2 diabetesincluding LEADER (liraglutide), SUSTAIN-6 (semaglutide), REWIND (dulaglutide), and EXSCEL (exenatide ER)found no significant increase in overall cancer incidence compared to placebo over follow-up periods ranging from approximately two to five years

Cycling Approach: Some practitioners implement protocols such as 12 weeks on, 4-8 weeks off to theoretically prevent receptor desensitization, reduce long-term costs, or provide physiological breaks

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