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NTS neurons that express preproglucagon (Ppg) (and that produce the food intakesuppressing PPG cleavage product glucagon-like peptide-1 [GLP1]) represent a subpopulation of mouse LepRbNTS cells

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Research has examined how glucagon receptor activation contributes to energy expenditure, hepatic lipid metabolism, and thermogenesis and crucially, how these effects interact with simultaneous GLP-1R and GIPR activation, a research question unique to tri-agonist compounds

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