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This severely biased the study population such that the true risk of developing NAION is likely much lower in a general population
The direct downstream targets of mTORC1 are ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4Ebinding proteins (4EBP) which regulate protein translation, cell size and cell cycle progression 7,8
If the room temperature exceeded 30C, or if the pen was frozen, the pen should be discarded
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