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In the drugs best showing so far, the ATTAIN-1 trial, people taking orforglipron lost on average 12.4% of their baseline weight, a notch below the roughly 14% weight loss seen in similar trials of Novo Nordisks injectable Wegovy and also below the typical results seen with Eli Lillys tirzepatide, a dual GLP-1/GIP medication
Plus, because the data comes from real-world hospitals and clinics, the results closely reflect how the drugs actually perform in everyday life, not just in a perfectly controlled lab setting. Using this database, Xiong and his colleagues will examine three main questions: Effectiveness : Do patients with mild cognitive impairment who take GLP-1s have a delayed onset of Alzheimers compared to those with no treatment or those taking the newly available biological drugs
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