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Collagen remodeling continues throughout this period, meaning skin benefits continue to develop even as the protocol progresses

NAION is a condition involving reduced blood flow to the optic nerve that can result in sudden, permanent vision loss

All experimental procedures were approved by the University of Calgary Animal Care and Use Committee and conformed to the guidelines of the Canadian Council on Animal Care as described in the Supplemental Appendix

Participants also showed improvements in glycaemic control, cardiovascular risk markers, and physical function, adding to the drugs clinical profile beyond simple weight reduction