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2 The patient's circulating plasma volume was 85% of the predicted value based on her sex, height, and body mass, suggesting modest hypovolemia
It enhances insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system effects
Alzheimers Disease International
Obesity SURMOUNT-1 Trial In adults with obesity (without diabetes): Tirzepatide (15 mg) : 20.9% average body weight reduction over 72 weeks Semaglutide (2.4 mg) (based on STEP trials): ~14.9% average reduction STEP 5 Long-Term Results Semaglutide also demonstrated durable effects: At 104 weeks, patients maintained ~15% weight loss on semaglutide 2.4 mg (STEP 5) SELECT Trial Cardiovascular Benefit Semaglutide significantly reduced major adverse cardiovascular events by 20% in people with obesity and pre-existing heart diseaseindicating benefit beyond weight loss
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