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There are several Phase 3 trials evaluating GLP-1s for conditions, such as metabolic dysfunction-associated steatohepatitis (MASH), prediabetes, Alzheimer's disease, diabetic retinopathy and osteoarthritis of the knee (in patients with obesity)
GLP-1 receptor agonist medications solve this by using modified versions of the GLP-1 molecule that resist enzymatic breakdown
Colognato R, Laurenza I, Fontana I, Copped F, Siciliano G, Coecke S et al
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