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For those concerned about side effects Tirzepatide has the best overall tolerability profile in clinical trials, with the lowest discontinuation rates
Additionally, a bioflavonoid complex has been added
In the ATTAIN-MAINTAIN trial, orforglipron's profile was "consistent with previous orforglipron Phase 3 studies." The most common adverse events were gastrointestinal-related and were generally mild-to-moderate in severity, which is expected for the GLP-1 class
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